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Apart from its role in modulating cell migration and cell death, src42A also regulates JNK-dependent dorsal closure.
In addition Bcl11b plays multiple roles in modulating cell migration, cell proliferation and hair follicle stem cell maintenance during cutaneous wounding [ 145].
Lysyl oxidases are copper-dependent enzymes with intracellular and extracellular activities, and catalyze the oxidation of lysine residues in collagen and elastin fibers, thereby modulating cell migration and epithelial differentiation [ 26, 27].
Androgen-responsive SRF target genes affect the progression of PCa cell behavior by modulating cell migration, which may have implications for therapeutic intervention downstream of AR and SRF [ 28].
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It has been shown that HSPGs may modulate cell migration by interacting with growth factors or chemokines and drives cell migrate toward specific stimuli [ 44].
Through this latter mechanism, SMARCA4 may serve to modulate cell migration and reduce the potential for invasion.
Also microbial factors like phospholipase C and LPS have been found to modulate cell migration (Firth et al. 1997; Häkkinen et al. 2000; Koff et al. 2006).
The ability of p27 to modulate cell migration has been previously ascribed by its ability to bind other proteins more directly implicated in the regulation of cellular motility, namely RhoA and stathmin [17], [19] [21].
N-cadherin expression levels can modulate cell migration and polarity by affecting integrin-based adhesions in tumor astrocytes [ 29].
Thus, AhR and Cav-1 could be acting in concert to modulate cell migration during normal and pathological situations.
However, paradoxically, TGF- β1 also modulates cell migration, invasion, angiogenesis, and the microenvironment in ways that cancer cells may exploit to their advantage.
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