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We show that phosphorylation of FLRT1 in the cytoplasmic domain modulates the ability of FLRT to activate the MAPK pathway and induce neurite outgrowth.
It is also possible that protamine binds to a flexible loop in the RyR that modulates the ability of protamine to act as a plug within the vestibule in a voltage-dependent manner.
Otherwise, it may be possible that the Hsp60 modulates the ability of IKKα or presumably IKKβ as well, to phosphorylate the other substrates such as RelA, SMRT, and histone H3 [52], which thus indirectly affects the NF-κB transcription.
This in turn modulates the ability of associated DNA to be transcribed.
In addition, it modulates the ability of merlin to suppress cell growth [ 34, 35].
Thus, we propose a model in which intracellular signaling modulates the ability of DEK to bind DNA, causing alteration of MHC class II transcription.
Similar(45)
The apoA-I molecule adopts a two-domain tertiary structure and the properties of these domains modulate the ability to form HDL particles.
Among the many efforts, one area of focus has been modulating the ability of antibodies to interact with the humoral and cellular components of the immune system through a process known as Fc engineering (Carter, 2006; Presta, 2008; Strohl, 2011).
This led us to hypothesize that additional structural elements could modulate the ability of tyrosine residues to form covalent bonds.
More recently, mInscutable and Gαi3, two known AGS3-binding partners, have been shown to modulate the ability of AGS3 to distribute along the aggresomal pathway [21].
Several studies have suggested that phosphorylation of ADAM cytoplasmic tails may (directly or indirectly) modulate the ability of ADAMs to cleave physiological substrates [16], [17], [19], [33].
Related(20)
modulates the fitness
modulates the determination
modulates the availability
modulates the abilities
release the ability
modulates the effect
modulates the interaction
modulates the insertion
modulates the redox
modulates the transcription
modulates the decay
modulates the signal
modulates the mineralization
modulates the error
modulates the tissue
modulates the viability
modulates the strength
modulates the contribution
modulates the expression
modulates the actin
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