Sentence examples for modulates the abilities from inspiring English sources

Here, we show that stabilizing alternative ATP-binding site conformations of the mitogen-activated protein kinases (MAPKs) p38α and Erk2 with ATP-competitive inhibitors differentially, and in some cases divergently, modulates the abilities of these kinases to interact with upstream activators and deactivating phosphatases.

While it appears that ATM modulates the ability of CTIP to promote Ku removal11, it is not yet clear what the impact of losing this function would be in ATM-deficient cells.

We show that phosphorylation of FLRT1 in the cytoplasmic domain modulates the ability of FLRT to activate the MAPK pathway and induce neurite outgrowth.

It is also possible that protamine binds to a flexible loop in the RyR that modulates the ability of protamine to act as a plug within the vestibule in a voltage-dependent manner.

Otherwise, it may be possible that the Hsp60 modulates the ability of IKKα or presumably IKKβ as well, to phosphorylate the other substrates such as RelA, SMRT, and histone H3 [52], which thus indirectly affects the NF-κB transcription.

In addition, it modulates the ability of merlin to suppress cell growth [ 34, 35].

This in turn modulates the ability of associated DNA to be transcribed.

Other difficulties arise from several sources of variability, including variation in virulence and pathogenicity of the microorganisms, variation in attack rates, variation in host susceptibility, and type of vehicle, which modulates the ability of pathogens to affect the host.

This modulates the ability of these GTPases to conduct their normal cellular functions without preventing Rab1-mediated fusion of vesicles with the Legionella-containing vacuole.

These data are consistent with the notion that FAK modulates the ability of activated Src to associate with and/or phosphorylate specific cellular substrates [ 27].

Thus, we propose a model in which intracellular signaling modulates the ability of DEK to bind DNA, causing alteration of MHC class II transcription.