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Ginger inhibits growth and modulates secretion of angiogenic factors in ovarian cancer cells.

KLK12 may then promote angiogenesis by the conversion of the membrane-bound platelet-derived growth factor B (PDGF-B) precursor into a soluble form that modulates secretion of the angiogenic vascular endothelial growth factor A (VEGF-A) [ 199].

Although multiple Rac1 and Cdc42 independent pathways affecting HIF1 transcriptional networks exist [ 36], it is possible that in HRasV12-transformed human fibroblasts, Rac1 may play a partial role in stabilizing HIF1 and/or activating JNK, which then modulates secretion of VEGF protein.

Nguyen and coworkers observed that activation of STAT3 signaling in tumor cells or in inflammatory immune cells modulates secretion of various inflammatory factors such as IL6 and TNF α that act as an immunosuppressors, and increase the probability of survival of tumor cells [ 69].

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In this study, the ability of Ti and rutile particles to modulate secretion of soluble factors involved in bone turnover has been assayed in an in vitro co-culture system of macrophages and human osteoblasts that allows the exchange of soluble factors between both cell types without direct cell contact.

Neuropeptides are believed to modulate secretion of classical neurotransmitters [ 79].

In co-cultures of macrophages and osteoblasts, pressure modulated secretion of sRANKL or OPG in a variable manner.

Oestrogens may alter cohesiveness of breast cancer cells and modulate secretion of proteases, thereby influencing invasive potential.

The filamentous fungus, Aspergillus niger, responds to nutrient availability by modulating secretion of various substrate degrading hydrolases.

Effects on monocultures of osteoblasts: For osteoblasts (from the same cell population) cultured without macrophages, pressure modulated secretion of both sRANKL and OPG.

In fat, FGF21 acts as a metabolic rheostat serving to modulate secretion of adipokines which in turn mediate discrete aspects of FGF21-induced physiology.

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