Sentence examples for modulates sumoylation of from inspiring English sources

In hepatocellular carcinoma HepG2 cells, PIAS4 modulates sumoylation of NEMO (NF- κB essential modulator), and NF- κB activation in response to DNA damage and knockdown of PIAS4 by siRNA in these cells inhibited NF- κB activation (Mabb et al, 2006).

Oestrogen may work in a similar way in the gonad by modulating sumoylation and/or ubiquitination of the SOX9 protein, trapping it in the cytoplasm.

This study also provided a new concept that SUMO and NF- κB ties are not simply one way but can be bidirectional, SUMO regulating NF- κB signaling on one hand and NF- κB modulating SUMOylation via induction of SUMO proteases on the other, thereby implicating new roles for the NF- κB system.

Rather, sumoylation of DRIL1 may modulate MAR-specific DRIL1 function.

Therefore, we wondered if sumoylation of these sites might modulate extracellular release of α-Synuclein.

Together, these data identify SUMOylation as a previously overlooked post-translational modification of Gli proteins that affects transcriptional activity and raises the possibility that regulated SUMOylation of Gli proteins functions to modulate Gli activity in vivo.

Based on these observed dramatic changes, we assume that SUMOylation of K82 in HSF2 more likely negatively modulates the interaction with DNA albeit more weakly than acetylation of K80 in HSF1.

Our results demonstrate that ER stress-induced degradation of SENP3 modulates protein SUMOylation.

Altogether, this study establishes sumoylation of DRIL1 as a novel and relevant control mechanism modulating DRIL1 function.

SUMOylation of a substrate can create a binding site and/or modulate conformation leading to the enhancement or decrease in binding affinity.

Our recent report [33] showed that site-specific phosphorylation of TR2 at Thr-210 modulates its association with the effector molecules PCAF and RIP140, albeit indirectly by increased SUMOylation of TR2 at Lys-238.