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Here, we used a post-expression cysteine (Cys -to-dehydrolanine (Dha) Cys -to-dehydrolaninetegy to identify a water-mediated motif that modulates aCys -to-dehydrolaninerotein tyrosine phosphatase A (PtpA) catalytic pocket.
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Previous authors have hypothesized that additional factors such as c-MYC and KLF4 facilitate reprogramming by modulating accessibility of the OCT4 and SOX2 loci [24], [25].
Nucleosome depletion or exchange at the promoter can modulate accessibility of DNA to transcription factors.
However, these amino acids might not only change the binding of GTP, but also modulate accessibility of the binding site for GTP or binding of some regulatory protein.
We cannot rule out that TRM4A contains other regulatory functions, for example regulating mC stability or modulating accessibility of mC sites to RNA binding proteins.
An alternative possibility is that the GTP-state of tubulin modulates the accessibility of the E-hook for EB1 binding.
Therefore, DNA compaction has clear functional implications, since it modulates the accessibility of genomic regions to regulatory proteins.
It has been shown that the nucleosome, a fundamental composing unit of the chromatin structure in eukaryotes, affects gene transcription in that it modulates the accessibility of underlying genomic sequence to proteins [ 18].
This particular method of grafting results in a complex polymer microstructure allowing for further development in the ability to modulate the accessibility of guests to a MOF.
To modulate the accessibility of N-terminal of the tau to heparin, the tau films on Au surfaces were fabricated in two ways: immobilization of tau via the N-terminal of tau protein (N-tau-Au) or by the Cys291/Cys322 residues, located in the R-repeat domains of the tau protein (Cys-tau-Au).
These data suggest that distinct cell types adopt precise histone codes to modulate the accessibility of TFs to the chromatin regions containing myelin genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com