Sentence examples for modulate the receptor from inspiring English sources

Flotillins have additionally been reported to modulate the receptor proteins on the membrane by altering their intracellular trafficking to membrane (Solis et al., 2012).

Mature hair cells express a rich variety and abundance of ion channels that serve to modulate the receptor potential, and altered expression of any may have functional consequences.

Phosphorylation sites are found in a long intracellular loop between TM3 and TM4, which may modulate the receptor activity [ 5, 6].

Membrane-associated mucins like MUC4 have become a focus of interest, as they function as intrinsic ligands and modulate the receptor tyrosine kinase ErbB2 (Carraway et al, 2003), an antiapoptotic pathway used by most types of common epithelial tumours (Yarden and Sliwkowski, 2001; Funes et al, 2006).

Since minimal concentrations of RANTES required for activation of CCR5 on T cells are between 1 and 10 nM 28, about threefold lower levels found in BAL derived from HIV-infected patient (2700 pg/mL; ∼0.35 nM) are unlikely able to modulate the receptor status, but indicate to a higher status of cell activation in the lungs of HIV-1-infected persons.

AF-1 integrates signals from AF-2 and other pathways to modulate the receptor's ultimate activity gene transcription.

Structural biology studies have revealed the structures of many GPCRs in atomic details and provide the basis for the identification and investigation of the potential ligands, which interact with and modulate the receptors.

Comparison of this structure with that of other peptide receptors suggests that endogenous peptide ligands with a high degree of conformational flexibility may bind and modulate the receptors via a similar two-site binding mechanism.

Correspondingly, the sharp focus on small molecules that the chemical view brings will give the molecular biology view ready access to reagents that can modulate the receptors that it has done so much to illuminate.

As this pathway has been shown to modulate the receptors endocytosis through endophilin phosphorylation and interaction with CIN85 (27, 27), we examined the level of its activation in Ophn1 −/y cells.

Further, modulating the receptor to reduce activation of c-Jun and calpain activity could counteract Aβ activation of these signaling intermediates.