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Whether modulation of the asialoglycan epitope by neuraminidase treatment also modulate the uptake of apoptotic cells, whether this will modulate their immunogenicity is a question that could also be relevant for tumor immunotherapy.
Previous studies suggest multiple relationships in response to N and K starvation, e.g., CIPK23 has been found to modulate the uptake activity of both the nitrate transporter, CHL1, and the potassium channel, AKT1, under nutrient deficiency conditions (Li et al. 2006; Xu et al. 2006; Ho et al. 2009).
This offers a possible strategy to modulate the uptake and release of nanomaterials.
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Because humans do not possess an active mechanism for iron excretion, this regulation is brought about largely by modulating the uptake of iron from the diet by the enterocytes of the proximal small intestine and transfer of this iron to the systemic circulation.
Studies carried out by Özvegy-Laczka et al. showed that multidrug transporters such as ABCG2 may be involved in the resistance to tyrosine kinase inhibitors such as Iressa by modulating the uptake and extrusion of these drugs to and from cells [ 43].
They are known to increase the epithelium permeability, modulate the vaccine uptake by APCs and the responses of lymphocytes (Cox et al., 2006).
Astrocytes are responsible for maintaining the environment of cells in the CNS: they provide nutrients and modulate the release and uptake of glutamate, electrolytes (Na+/K+) and other by-products of neural activity [ 78].
Ferric uptake regulatory protein (FTT_0030) is modulating the iron uptake system in F. tularensis subsp. tularensis[ 9], and no other gene has been found in this genome regulating iron content.
The Spacer molecule mainly determines the overall pattern, modulating the cellular uptake process.
This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine and presents an account of ligand-targeted nanoparticles for receptor-mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles.
Therefore, these results suggest that helper lipid composition is a crucial step to be considered in the design of niosome formulation for retinal gene delivery applications since clearly modulates the cellular uptake, internalization mechanism and consequently, the final transfection efficiency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com