Sentence examples for modulate the autophagic from inspiring English sources

In conclusion, turnover of FoxO1 may be an important mechanism that allows cells to modulate the autophagic process.

All together these qualitative and quantitative analyses allow us to conclude that microgravity is able to positively modulate the autophagic process in TCam-2 seminoma cell line.

In this study, we demonstrated that EETs modulate the autophagic response in starved cardiac cells through mechanisms involving pmKATP channels and AMPK.

AMPK is able to modulate the autophagic machinery by affecting two crucial signaling complexes: by inhibiting MTOR and, as recently revealed, by directly phosphorylating ULK1.

Our results also suggest that the basal levels of TIGAR expression seen in our cell culture models (that are p53 dependent) are sufficient to modulate the autophagic response and that no increase in TIGAR expression is necessary.

14 Since we observed that As2O3 treatment decreased TAK1, we next assessed whether reducing TAK1 levels could alter As2O3-induced changes in SnoN and thus, modulate the autophagic pathway.

Mitochondrial aldehyde dehydrogenase (ALDH2) has been implicated in cardioprotection from ischemic injury by both modulating the autophagic pathway and through inhibiting formation of 4-hydroxy-2-nonenal 4-HNE -proteinn adducts [4-HNE -protein

Interestingly, the protective effect involved modulating the autophagic response, thus shifting the cell death process to promote cell survival.

Our previous study demonstrated that CASP2 modulates the autophagic response against mitochondrial oxidative stress in primary neurons.

Thus, we sought to determine whether Bcl-2 has a role in modulating the autophagic response observed in our sPD models.

Our in vitro and in vivo findings suggest that metformin exerts antineoplastic activities through downregulation of Stat3 signaling; that is, Stat3 modulates the autophagic process induced by metformin in addition to its participation in cell proliferation and apoptosis.