Sentence examples for modulate its activation from inspiring English sources

Interestingly, not only does c-Src bind directly to Y1057, but c-Cbl provides an additional mechanism for c-Src to interact with VEGFR-2 by serving as an "adaptor" which in turn may modulate its activation by VEGFR-2.

One possibility is that His11 interacts with the sweet taste receptor directly to modulate its activation; the other is that His11 induces a conformational change in neoculin in a pH-dependent dynamic equilibrium between active and inactive forms, as described in our previous model [16].

Shorter time points will be necessary to set Wnt activation, in order to modulate its activation and couls study their effect on CKD activation.

Moreover, 14.3.3 protein, which is known to bind IRS-1 and modulate its activation, was not significantly different between normal and OA Obs (data not shown).

First, 14.3.3 protein, which is known to bind IRS-1 and modulate its activation [ 19], was not significantly different between normal and OA Obs, and thus is unable to explain the underphosphorylation of IRS-1 in OA.

However, at least one such stimulator, TNFα, does not stimulate the transcriptional activity of ZONAB (data not shown), suggesting that additional signalling mechanisms act on ZONAB to modulate its activation.

These sialoglycoproteins could therefore interact with GSK-3 β, modulating its activation status based on the level of sialylation.

In agreement with this hypothesis, the different action of ceramide on SGK-1 and AKT-1 may be, at least in part, dependent on the absence of pleckstrin homology (PH) domains in SGK-1, which is pivotal for the interaction of PDK-1 and AKT-1 with plasma membrane phosphoinositides, modulating its activation.

Hence, NOD2-S represents a down-regulatory loop by which NOD2 is able to modulate its own activation.

This is why a network of positive and negative feedback loops, which most likely evolved to fine-tune the activity of this tumor suppressor, modulate its induction and activation.

This finding suggests a dual-layered mechanism of transcriptional regulation, comprising both a continuum of binding-site occupancy by each PIF and a superimposed layer of local regulation that acts differentially on each PIF, to modulate its intrinsic transcriptional activation capacity at each site, in a quantitative pattern that varies between the individual PIFs from gene to gene.