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Our findings consistently showed syndecan-1-dependent effects on collagen matrices indicating that this proteoglycan affects specific cell-matrix interactions to modulate its effect on cell migration.
However, when VEGF-A165 was present, they did not in any way modulate its effect on iBREC proliferation.
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Importantly, when combined, 4αPDD positively interacted with hyperosmolarity to modulate its effects on tensile stiffness and collagen content.
We found that although BDNF mediates exercise-induced hippocampal plasticity, additional molecules, i.e. the N-methyl-d-aspartate receptor, calcium/calmodulin protein kinase II and the mitogen-activated protein kinase cascade, modulate its effects.
Third, leptin can modulate its effects on human Ob via an inhibition of apoptosis [ 36], and we observed a reduction in Bax-α to Bcl2 expression in OA Ob compared to normal Ob [ 45] an indication of reduced apoptosis.
A reciprocal gradient of Draxin might shape or sharpen the active Netrin gradient, thereby critically modulating its effect.
There is evidence that the timing of exercise relative to a memory task modulates its effect.
The defect was linked to the endothelium because no differences were observed in flow-independent vasodilation (which is the response to sublingual nitroglycerin, modulating its effect at the level of the arterial smooth muscle).
Proinflammtory cytokine secretion (IL-1β and IL-6) by the epithelial cells was also regulated by KSL-W in a manner similar to that of antifungal molecule amphotericin B. These findings therefore show that KSL-W is safe for use with human cells and is able to attenuate Candida virulence by modulating its effects on host innate immunity.
Sound physiologic principles underlie the possible mechanisms of CO2 action, modulating its effects on the skin and subdermal layers.
The cytokine modulates its effects through the c-met tyrosine kinase receptor and misregulated expression of both cytokine and receptor is a common finding in many tumour types (Trusolino and Comoglio, 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com