Sentence examples for modulate its aggregation from inspiring English sources

Identification of proteins that physiologically bind Aβ and modulate its aggregation and neurotoxicity could lead to the development of novel disease-modifying approaches in AD.

The two free cysteines of SOD1, especially Cys-111, have been recognized to modulate its aggregation propensity.

Tau phosphorylation can induce conformational changes that subsequently modulate its propensity for self-aggregation [15], [16].

We have previously reported presence of the glucocorticoid (GC) receptor (GR) alpha on blood platelets, and its ability to modulate platelet aggregation when activated by the synthetic GC prednisolone (Pred).

Given that αSynuclein is a very abundant protein in mammalian brain [ 19] it is likely that mammalian neurons have developed mechanisms to modulate αSynuclein aggregation, which do not exist in invertebrate neurons.

Molecular chaperones modulate the aggregation and toxicity of the huntingtin (Htt) protein by an ill-defined mechanism.

Here, we designed and synthesized iminodiacetic acid-conjugated nanoparticles (IDA-NP) to modulate Aβ42 aggregation and reduce the cytotoxicity accelerated by Zn2+.

Tremendous efforts have been made to modulate their aggregation behaviors to suppress nonradiative decay in order to achieve efficient light emission and long lifetimes.

These two cell compartments have quite different redox properties, which could further modulate the aggregation process in vivo.

A number of in vitro studies showed that dopamine can modulate the aggregation of α-synuclein by inhibiting the formation of or by disaggregating amyloid fibrils [5], [6], [7].

This would resolve, together with our findings showing that the extra N-terminal amino acids modulate the aggregation properties of Mca1, the discrepancy in the conclusions regarding the prion properties of Mca1 that are present in the two studies [11], [13].