Sentence examples for modifications in regulation from inspiring English sources

These observations highlight a role of DNA methylation and histone modifications in regulation of lineage-specific gene expression, and in maintenance of lineage determination in the embryo.

As ES cells are exquisitely sensitive to changes in Oct4 protein levels [14], this directly suggests that there must be an active mechanism for marking existing Oct4 protein for degradation and raises the possibility of post-translational modifications in regulation of Oct4 levels and, by extension, maintenance of ES cell pluripotency.

The involvement of histone modifications in regulation of key aspects in musculoskeletal biology-for example, in inflammation [ 29- 33] or differentiation [ 34- 36]-has recently been established.

To test the function of Nucleoplasmin post-translational modifications in regulation of its function, we determined its full complement of PTMs, characterized their dynamic changes during development, and tested their role in modulating plasmid supercoiling.

Further evidence for the role of posttranslational modifications in regulation of the features of membrane-less organelles is provided by the observation that the amino acids arginine, serine and tyrosine are overrepresented in the low complexity sequences of proteins within them.

Therefore, the posttranslational modifications status in regulation of VHL E3 ligase activity remains understudied.

These data are in accordance with our results, suggesting that dynamic changes of H3K9 modifications participated in regulation of biological events essential to MSC osteogenic differentiation.

In order to better understand the factors that contribute to epigenetic regulation, we have been investigating the role of histone modifications in the regulation of gene expression during the Simian Virus 40 (SV40) life cycle [ 4– 9].

The adaptations involved in this process are modifications in the regulation of metabolic and physiological processes that decrease plant yield and performance when grown out of their appropriated growth conditions.

This indicates that space flight during prepuberal age may induce irreversible modifications in the regulation of oxytocinergic neurons, which in turn may result in permanent endocrine and behavioral impairments.

Recent studies have highlighted the importance of post translational histone modifications in transcriptional regulation of genes.