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These changes were not associated with modifications in gene expression.
Roundtree, I. A., Evans, M. E., Pan, T. & He, C. Dynamic RNA modifications in gene expression regulation.
cDNA microarrays were used to investigate GH-induced modifications in gene expression in the tibial growth plate of young rats.
Modifications in gene expression, including those of the kallikrein-related peptidase family, have been portrayed in gastric carcinogenesis.
Together, these results indicate that TAG biosynthesis and secretion in Bayberry is achieved by both up and down-regulation of a small subset of genes related to the biosynthesis of cutin and saturated fatty acids, and also implies that modifications in gene expression, rather than evolution of new gene functions, was the major mechanism by which Bayberry evolved its specialized lipid metabolism.
While much research has focused on DNA modifications that stimulate or inhibit this gene expression, the impact of RNA modifications in gene expression received scant attention until 2011.
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Our data reveal physical activity level dependent epigenetic modifications in genes involved in muscle structural dynamics, energy metabolism, and predisposition to T2D.
This is a very important step in the theoretical framework of astrocyte-mediated epileptogenesis, because a plausible link between albumin activation of astrocytes and changes in neuronal excitability could be through modifications in gene-expression.
It is of great interest that we found signatures of histone modifications in genes in cancer pathways.
Almost all human cancer types contain epigenetic alterations that contribute to cancer development due to the regulatory role during transcription of epigenetic modifications in genes [ 2].
Studies of pancreatic islets from nondiabetic donors (19, 20) and patients with T2D (21) have identified epigenetic modifications in genes that potentially affect β-cell function.
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