Sentence examples for modifications in mouse from inspiring English sources

The score indicates how reliable the edge is based on experimental or genomic annotation information and should be between 0 and 1. TimeXNet provides a comprehensive network of weighted protein-protein, protein-DNA interactions and post-translational modifications in mouse.

Using immunofluorescence and multi-color confocal microscopy analysis, we assessed changes in the expression of certain histone modifications in mouse and human embryos at the protein level (Fig.  1A and B).

This finding was further confirmed by performing ChIP against ATRX, H3.3, H3K9me3, and the activating H3K4me3 modifications in mouse ESCs derived from a similar female SV129 × Cast male cross.

In this study, we have investigated a range of histone modifications in mouse nuclei transplanted to X. oocyte GVs in order to ask whether histone modifications are changed at the nuclear or chromatin levels.

Analysis of expression and localization of histone modifications in mouse embryos indicated that each blastomere exhibited similar epigenetic marks during the early cleavage stages of development both by single-frame confocal imaging (Fig.  3B and Supplementary Material, Fig. S3a) and three-dimensional modeling of Z-stacked confocal images (Fig.  3D).

He won the Nobel Prize in Physiology or Medicine in 2007 for his contribution to the discovery of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.

In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice through embryonic stem cells, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine.

In 2007 Capecchi, Evans and Smithies received the Nobel Prize 'for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells'; they used homologous recombination in embryonic stem cells [ 66].

In general, these models were created by introducing genetic modifications in mice that resemble the genetic defects of IBD patients, or by relying on external disturbances to induce disease.

To our knowledge, no studies have evaluated whether high-fat diet/obesity offsets the protective effect of other genetic modifications in mice such as ablation of Adamts5 or Mmp13.

Furthermore, increasing IKr by overexpression of hERG currents, either by adenoviral transfer in the rabbit or guinea pig or by transgenic modification in mouse was reported to shorten APD (Nuss et al., 1999; Royer et al., 2005).