Sentence examples for modifications in vitro from inspiring English sources
Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifications, in vitro and in vivo stabilities, and in vivo performances.
In this review, we focused on describing the structure activity relationships (SARs), structural modifications, in vitro or even in vivo pharmacodynamics and pharmacokinetics of BMS-378806 and its analogues as HIV-1 gp120 attachment inhibitors.
GFAP has recently been reported as highly vulnerable to proteolytic modifications in vitro and in vivo.
The high proliferation capacity of PKCs facilitates the introduction of precise and complex genetic modifications in vitro.
Importantly, these noncognate enzymes enabled us to change the pattern of PTMs, leading to the introduction of unnatural modifications in vitro.
In addition to endogenous metabolite levels, metals and other environmental pollutants have been shown to alter epigenetic patterns, including global DNA methylation and histone modifications in vitro and in vivo (Byun et al. 2013; Hou et al. 2012).
However, Omacor increased the susceptibility of LDL to oxidation, whereas gemfibrozil did not affect the resistance of LDL to oxidative modification in vitro.
After 12 weeks of Omacor treatment LDL appeared more prone to oxidative modification in vitro than LDL after gemfibrozil treatment, as measured by the significantly decreased lag time, preceding the onset of the lipid peroxidation.
Although mostly characterized in the context of PARP1-dependent poly(ADP-ribosyl)ation, histone H1 modification in vitro by PARP3 has been reported recently [6], [48] supporting the notion that PARP3 could also participate in chromatin remodelling at specific loci.
We find that loading of PCNA onto DNA is a prerequisite for sumoylation in vivo and greatly stimulates modification in vitro.
Our efforts to reconstitute PCNA modification in vitro have given important insights into a mechanism of poly-ubiquitin chain formation that is distinct from previously analysed examples.
