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The results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium selenite.
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The compounds 5a,b and 6a,c showed modifications in rat uterus at 35.7 34.8 nM levels with privileged endometrial thickening effect and least change of uterine weight relative to NEA at 52.9 nM level.
Our preliminary results indicate that acute administration of RP promotes significant modifications in rat isolated aorta vascular tone, mainly by reducing endothelium-independent relaxation.
The aim of this study is to characterize the possible effects of urine sample modification in rats, and to use this information to improve the quality of data analysis for single metabolite quantification and for future metabonomic studies.
Mausset-Bonnefont, A. L. et al. Acute exposure to GSM 900-MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain.
D. M. Chandrupatla et al. made modifications in a rat model of rheumatoid arthritis (RA) to widen the therapeutic window for PET-guided evaluation of novel anti-RA agents.
Maekawa, R. et al. Changes in gene expression of histone modification enzymes in rat granulosa cells undergoing luteinization during ovulation.
Ashby et al. reported advanced vaginal opening by 1.1 days without modifications on uterine weight in rats by effect of prenatal plus prepubertal exposure to BBP, although the authors considered that this result could be related to the variability of the observation or, more interestingly, to an increase in the weight of the BBP treated animals [ 21].
However, due to the lack of genetic tools for site-specific genetic modification in the rat genome, more and more researchers chose the mouse as their favored mammalian models due to the sophisticated embryonic stem cell-based gene-targeting techniques available.
Ethanol has also been demonstrated to be associated with post-translational histone modification in a rat model [ 49- 51].
These issues must be resolved to achieve the efficiency of ES cell-based genetic modification in the rat that has been achieved in the mouse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com