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In this study we investigated the effects of co-injection of bFGF with temperature-responsive chitosan hydrogel on myocardial performance in a rat model of infarction.
We have investigated the anti-ischaemic and antiarrhythmic effects of riluzole, a selective INaP blocker, in an open chest pig model of infarction.
Fasudil was shown to inhibit neutrophil infiltration in a cerebral model of infarction (Satoh et al., 1999).
Their finding closely correlate with our findings in the rat experimental model of infarction that we have currently used.
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To verify this, we used a rat model of infarction-induced heart failure (n = 12 per group).
Cardiomyocytes have been successfully obtained from iPS in vitro [ 24] and their transplantation in animal models of infarction resulted in improved myocardial function [ 25].
In a mouse model of myocardial infarction, IK-1001 reduced infarct size, reduced neutrophil infiltration, attenuated the inflammatory response, and improved contractility.
Coronary artery ligation, mimicking ischemic injury that leads to myocardial infarction in human, is commonly used as model of myocardial infarction in mice.
In this study, we used the myocardial infarction model described by Wu et al., which is a validated animal model of myocardial infarction [ 13].
The gel was then tested in a rat model of myocardial infarction.
The printed biocomplex was transplanted in a mouse model of myocardial infarction (MI).
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