Further linkages between this mouse model of disease, healthy mice, healthy humans, and diseased humans simply do not exist at present but are clearly justifiable for future research.
And we physicians have been drawn to the toggle-switch model of disease and health: the biopsy was positive; the blood test was negative; the scans find "no evidence of disease".
Maizels et al. [15] established a group-based model of disease management for patients with headache.
To develop a model of disease progression using multiple sclerosis (MS) as an exemplar.
Conclusions: This strategy is expected to generate proof-of-principle for viroimmunotherapy in a highly stringent model of disease.
An alternative approach could be to characterise disease progression using an alternative concept, such as dependence, or a multi-domain model of disease progression [50, 51].
More recent medicine has tended to weaken this slightly by adopting what Green (2007, ch, 2) calls an 'actuarial' model of disease.
We have further characterised the effects of these two mutations in combination with the Z mutation in a eukaryotic cell model of disease.
These mutations preserve inhibitory activity but reduce the polymerisation of wild-type native α1-antitrypsin in vitro and increase secretion in a Xenopus oocyte model of disease.
This model of disease development drove the logical deduction that early detection, by "breaking the chain" of cancer development, must be of benefit to affected individuals.
Our suggested model of disease transmission strengthens this hypothesis.
