Sentence examples for model accumulation of from inspiring English sources

In an ischemia rat model, accumulation of zinc was observed specifically in degenerating neurons in the hippocampus, and intraventricular injection of Ca-EDTA could reduce zinc accumulation and prevent hippocampal neurodegeneration [11].

Under the stress model, accumulation of all three of these RNAs was predicted to be reduced by stress.

This is consistent with our multi-step model (accumulation of an intermediate), and we believe this provides evidence for a more complex operation of the D1R CTS.

These findings agree with the observations by Sharma et al. [ 49], who found that, in the non-ischaemic cardiac HF model, accumulation of lipids was most pronounced when heart failure was associated with diabetes and obesity.

In our HFD-induced mouse NAFLD model, accumulation of lipid in liver and marked increase in body weight are usually observed at 24 weeks, but slight at 12 weeks, after the start of HFD [ 28].

In this neuronal in vitro model, accumulation of both amyloid precursor protein (APP) and the 28-kDa active form of presenilin 1 (PS1) (endowed with α-secretase activity) is observed as early as 30 min after administration of neutralizing anti-NGF antibodies; the simultaneous addition of NGF to the cultures prevents such biochemical modifications.

In experimental mouse models, accumulation of aggregated tau is associated with memory deficits and neurodegeneration [ 6, 40, 41].

In animal models, accumulations of these cytokines have been observed in remote organs, including the heart, brain and lungs.

Acquisition of one mutation will not necessarily reduce the clinical efficacy of a regimen; thus we did not model the accumulation of mutations, we modeled the virological failure rate due to acquired resistance.

The developed model of accumulation of large missing pieces per number of handlings of a document depending on DP, enables us to calculate the time required for an object to become unfit for use by readers in the context of general access.

Histopathologically, the mouse model demonstrated accumulation of abnormal lysosomal inclusions in multiple tissues and neuronal cell loss with concomitant astrocyte activation [18], [19].