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For example, accumulation of biological produced POC was found at the pycnocline of Chukchi Shelf [42], where bacteria amount provided from the bottom is relatively small.
Hence, its potential still remains partially unexploited, largely because of a lack of general consensus and public concerns regarding the lack of effectiveness and control, poor reliability, and possible occurrence of side effects, for example accumulation of toxic metabolites and pathogens.
For example, accumulation of p53 has recently been shown inhibit HIF-1α activity and thereby hinder angiogenesis during the later stages of severe pressure overload hypertrophy progressing to contractile failure [41].
For example, accumulation of virions on cell surfaces by tetherin may promote recognition of infected cells through the deposition of antibodies and subsequent clearance by phagocytes.
Other processes, for example accumulation of extracellular matrix, could contribute to the accelerated kidney damage caused by diabetes mellitus in combination with hypertension.
For example, accumulation of diacylglycerols, but not triacylglycerol, is associated with insulin resistance in non-adipose tissues (Chabowski et al. 2012).
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It cannot be excluded that these changes may affect caspase activity, as well as, for example, accumulation and intra-cellular trapping of cisplatin.
For example, the accumulation of evolutionary novelties can be followed over time.
When the position of equilibrium is unfavourable, for example, the accumulation of products may cause a reversal of the reaction.
The side-effects start even before we are born, they go on throughout life and they are manifested as, for example, the accumulation of various types of molecular garbage inside cells and outside cells, or simply as cells dying and not being automatically replaced by the division of other cells.
For example, the accumulation of autofluorescent compounds, as observed under UV light, was lower in the mutant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com