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We speculate that Mrp1 protein down-regulation observed in jaundiced jj Gunn rat pups and maintained into adulthood, may increase the central nervous system accumulation of toxins or drugs, impair immune and endocrine response, and lead to increased oxidative stress impairing neuronal development independent of bilirubin itself.
These results also clearly show that due to the lower activity of the ascorbate-GSH antioxidant system accumulation of H2O2 caused high damage to chlorophylls.
Although GCIs can occur widely in the central nervous system, accumulation of phosphorylated α-synuclein in Schwann cells has not been reported in MSA.
Moreover, Spica Prunellae is believed to possess anti-cancer activity since in traditional Chinese medicine (TCM) system, accumulation of heat and toxic dampness is a major causative factor for tumorigenesis.
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In the case of drug delivery systems, accumulation of particles directly affects their reliability, especially when considering long-term applications.
He suggested that the inevitable structural decay that accompanies such transactions could be delayed, although not reversed, by the system's accumulation of energy from outside.
The axial channel provenance system and accumulation of natural gas of the Upper Miocene Huangliu Formation in the Qiongdongnan Basin was analyzed.
Additionally, this fertilizer was expected to complement declination of body absorptivity, cohesion and sedimentation, necessity of a nutrient solution supply system, and accumulation of soil salt and environmental contamination, which will improve the convenience of use and profitability in farm cultivation.
Although many of these species will be in lower frequency compared to the dominate species of the system, the accumulation of the lower frequency species can quickly result in a dominant functional influence.
Several neuropathological features are common to FBD, FDD and Alzheimer's disease (AD): amyloid deposition and neurodegeneration in the central nervous system (CNS), accumulation of complement proteins and their pro-inflammatory activation products, including iC3b, C4d, Bb, and C5b-9, neurofibrillary pathology and hyperphosphorylated tau [12], [13], [14].
Improvement of long-term imaging system and accumulation of data are required to answer this question.
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