Sentence examples for matrix accumulation of from inspiring English sources

Buffer or matrix accumulation of citrate and α-KG was apparent with FAO, and the magnitude dependent on rate.

In hypoxic conditions there was increased matrix accumulation of proteoglycan but less cell proliferation, which resulted in 3.5-fold more glycosoaminoglycan per DNA after 14 days of culture.

Apparently, collagen III is not fully representative for interstitial fibrosis, which is a reflection of interstitial matrix accumulation of many different extracellular matrix molecules.

Histological analysis clearly showed adipocytes containing lipid droplets, matrix accumulation of sulfated glycosaminoglycans in cell pellets, and areas of mineralization in cultures maintained under adipogenic, chondrogenic, and osteogenic conditions, respectively.

Myofibroblastic (MFB) differentiation and matrix accumulation of HSC are usually induced by profibrogenic mediators like TGF- β and the β-isoform of platelet-derived growth factor (PDGF) [ 16– 20].

One possible explanation for these unexpected results is that the angiotensin II-mediated signaling pathway may not contribute to the onset of microalbuminuria and mesangial matrix accumulation of the kidney in early diabetic normotensive patients with normoalbuminuria.

Podocyte derived CCN2 has also recently been proposed to have a paracrine effect on mesangial cells resulting in augmented profibrotic signalling and matrix accumulation independent of active TGFβ [ 31].

Histological investigation displayed typical patterns of UUO renal disease, including tubular dilatation, flattening and atrophy, and expansion of interstitial area with extracellular matrix accumulation and infiltration of inflammatory cells.

The following parameter were determined as reported previously [21]: To quantify mesangial matrix accumulation and sclerosis of the glomerular tuft, a score of 0 to 4 was determined on PAS and HE stained paraffin sections (GSI  =  Glomerulosclerosis index).

However, knockdown of DKK1 attenuated mesangial matrix accumulation via the restoration of the activation of Wnt/ β-catenin signaling under hyperglycemia conditions [ 52].

Matrix metalloproteinases, a family of proteolytic enzymes are thought to be involved in extracellular matrix accumulation during development of hypertensive target organ disease.