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Conceivably, infliximab treatment might reduce cell migration as well as retention of inflammatory cells in the skin and synovial tissue.

We therefore asked whether blocking sources of ROS generation might reduce cell death in the low magnesium model.

Consequently, NCAM upregulation observed in CDDP- and VCR-resistant NB tumour cells under VPA might reduce cell transmigration and extravasation processes.

The ceramide signaling pathway, which might reduce cell death, was activated at 12 h, while caspase cascade was activated rapidly at 24 h.

Since SENP3 levels correlate with cytochrome c release, and SENP3 recovers during reoxygenation, we reasoned that removing SENP3 or promoting SUMO-2/3-ylation during reoxygenation might reduce cell death post-OGD.

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Interestingly, LIMK1 was one of the genes downmodulated following CHKA silencing (see Table 1) and a reduced phosphorylation of the LIMK1/cofilin pathway at later time point after scratching was observed in CHKA-silenced cells (data not shown), suggesting that a long lasting dephosphorilation by impairing actin polimerisation might ultimately reduce cell migration (Mizuno, 2013).

Finally, as EBV reactivation might also reduce cell viability, we tested the effects of nutlin-3 and ABT-737 on production of the viral BZLF1 protein, a transcriptional activator that mediates the transition between the latent and lytic cycles of EBV.

MiR-143 was frequently downregulated in colorectal carcinoma tissues, the restoration of which in colon cell lines might reduce tumor cell growth and soft-agar colony formation [ 43, 44].

First, blockade of NKp46 might reduce NK cell activity before IFNα treatment and improve the subsequent NK cell response.

Next, we measured the effect on BPH1 cell proliferation in our reconstituted tumours, because CAF modification might reduce BPH1 cell proliferation and account for the decrease in tumour volume.

Therapy targeted against PRC2 might reduce tumor cell plasticity and heterogeneity, metaphorically "freezing" the ability of tumor cells to adapt, and provide a new paradigm in the treatment of gliomas.

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