Sentence examples for might decrease cell from inspiring English sources

A mechanism does exist by which agonist thyroid hormone (T4 or T3) might decrease cell P-gp activity, as tetrac appears to do via αv β3.

Therefore, our follow-up experiments focused on trying multiple low doses of S-NPAA that might decrease cell viability in the tumorigenic prostate cell lines but cause minimal decrease in the viability of the nontumorigenic RWPE-1 cells.

Thus, we hypothesized that neuronal differentiation following miR-124 overexpression might also decrease cell tumorigenicity.

A plausible explanation as to why NK cells might specifically decrease cell-surface HLA-A expression upon activation is to reset the threshold of inhibitory receptors (e.g., KIRs, LILRs) for NK cell killing, as reported between murine Ly49 and MHC-I where cis H2Dd sequesters Ly49A, relieving NK cells from the suppressive effect of unengaged Ly49A (Held and Mariuzza, 2008; Chalifour et al, 2009).

An increase in doubling time was observed for M 2-knockdown mouse SFs, which could be an indication that M2 might directly or indirectly decrease cell proliferation ability via interacting with other genes.

In this study, we hypothesised that the inhibition of HA synthesis by MU in osteosarcoma cells might decrease the formation of cell-associated matrices, thereby leading to the suppression of tumourigenicity and of metastasis.

In case neighbouring cells are missing, like it is e.g. the case for disseminated tumour cells, cells might decrease levels of EpCAM activation, receive less proliferation signals, and might rest in a state of quiescence (condition D1).

After confirming that PEMT, PSS1 and PSS2, which mediate the synthesis of PS [37], are expressed in B lymphoblasts (Supplementary Information, Fig. S5 online), we predicted that high COMT activity might decrease PS in cells via competition with PEMT for SAM, especially in serum-free culture, where exogenous PS, PC and cholines are unavailable.

Our data implied down-regulation of HSP genes expression in RXRα-deficient hepatocytes might result in decreased cell protection ability and consequently render the cells prone to death.

However, SEMA4D is rare in B-cell non-Hodgkin's lymphomas, suggesting that its loss might lead to decreased cell adhesion, increased mobility and metastatic potential (Dorfman et al, 1998).

In disorders in which glial and immune cells contribute less to disease pathogenesis, targeting these cells might decrease the effectiveness of a treatment, because glia can have a high endocytic or phagocytic capacity for drug compounds.