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Additionally, the PDT-induced defect of mitochondria and the release of Ca2+ into the cytoplasm might trigger cell apoptosis or necrosis, which may result in the cell morphology and cytoskeleton defects eventually.
These findings suggest that HrpN might trigger cell death associated with cytoplasmic shrinkage and chloroplasts browning.
This phenotype might be directly relevant to infant-onset SCA13 because interaction with inappropriate synaptic partners might trigger cell death during brain development.
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As a general concept these processes put a burden on the protein degradation machinery and might therefore also trigger cell death.
Indeed, the enzyme is present in nearly all cancer cells, but isn't found in most normal mature cells, which suggests that telomerase might trigger unfettered cell multiplication.
To gain further insights on how water extracts of I'm-Yunity™ (PSP) might trigger G1/S cell cycle arrest in HL-60 cells, we determined the expression of the retinoblastoma gene product Rb, known to play a pivotal role in controlling the G1/S phase transition via a cyclin kinase-mediated, switch on/off mechanism of the binding of transcription factor E2F [ 33, 43, 44].
Hyrtios sp. might trigger the cell death induced by DNA damage.
Alternatively the expected increased calcium influx might trigger retinal cell death and thereby cause an overall loss-of-function.
In Leishmania spp., CPT activates a cell death pathway via deregulation of the mitochondrium [ 25], thus implying that also in T. gondii, impaired mitochondrial function might trigger a cell death pathway which finally leads to DNA fragmentation.
To test whether reduced muscle motility, altered innervation, or fibre atrophy/regrowth might trigger satellite cell changes in some individuals, we examined PMP22 C22 transgenic mice that all show signs of disease, but have a heterogeneous progression.
Therefore, the molecular mechanism of anticancer agents interacting with the Ras/Raf/ERK pathway is still unclear; clarifying it could lead to the identification of new molecular targets that might be manipulated to trigger cell death in cancer cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com