On a larger scale, a high density of osteons might reduce overall tissue density while increasing toughness, simply because osteons absorb or deflect cracks [109].
By limiting endothelial dysfunction, vitamin C might improve tissue perfusion and reduce tissue hypoxia and subsequent organ dysfunction.
As GAG depletion and cyclic loading of samples have both been reported to reduce tissue hydration, it might be speculated that the increased reduction in failure properties of these sample groups post stress relaxation might be directly related to sample dehydration.
The lower levels of adiponectin in the early stage of disease, when progression of skin fibrosis is thought to be the most active, might reflect reduced tissue PPAR-γ activity.
One might expect that reduced tissue oxygen tension would elicit angiogenesis and hence a 'physiological' recruitment of new vessels to improve tissue oxygenation.
Decreased systemic production of IL-6 in AMD3100-treated maye may be an indirect effect of inhibition of CXCL12-mediated cell traffic, as this might reduce formation of inflammatory tissue in joints and possibly other sites in the CII/CFA-immunized mice.
In the liver Layer et al. [ 28] demonstrated that connective tissue only lead to a weak increase in the grey-level intensity, whereas the addition of connective tissue to a given tissue lipid might reduce the image brightness.
However, PaO2 also is an important determinant of PbtO2[42] and additional pathological events (e.g., impaired lung function [43] or impaired O2 extraction due to increased gradients for oxygen diffusion in injured brain tissue [17]) might reduce PbtO2, in the absence of reduced CBF.
Therefore, patients with impaired CDA activity might develop strong toxicities after administration of gemcitabine, while CDA overexpression in tumour tissues might reduce the antitumour efficacy of this drug.
However, PaO2 also is an important determinant of PbtO2[ 42] and additional pathological events (e.g., impaired lung function [ 43] or impaired O2 extraction due to increased gradients for oxygen diffusion in injured brain tissue [ 17]) might reduce PbtO2, in the absence of reduced CBF.
