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We also tested the hypothesis that HIV-1 might directly induce Sn expression on monocytes.

Thus, portal IL-6 from visceral fat might directly induce the production of CRP in the liver.

In this study, we hypothesized that hyperammonia might directly induce a series of changes leading to liver injury.

Moreover, TSA might directly induce Treg through acetylation of Foxp3 or TSA might modulate dendritic cell function to indirectly induce Treg [ 44].

Along that line, damage or hypoperfusion of the brain (WMH) might directly induce realise of NT-proBNP from the brain [ 20].

OxLDL might directly induce proliferation and differentiation of stem cells present within the ligaments, or indirectly by enhancing growth factor production in synovium.

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Finally, our results indicate that death receptors overexpression might be directly induced by γ-irradiation, whereas the death receptors ligands overexpression might be the consequence of the mitotic catastrophe in response to blockage of cell cycle checkpoints or abnormal mitosis (29).

These data suggest that rapid-onset apoptosis occurs in S2 in the tumor tissues following cryoablation, which might be directly induced by low temperature, while there exists a delayed wave of apoptosis in S3, whose mechanism is unknown.

The probability of this selection scenario was considered higher particularly because it is unknown how frequently josamycin might be able to directly induce 23S rRNA gene mutations, especially during treatment of M. genitalium with a very long generation time.

Indeed, it might not be necessary for metformin to directly induce senescence in oncogenically primed cells.

It can then be deduced that STAT-5 activation might be more important for promoting survival of autoreactive nTreg cells than to directly induce foxp3 expression in the murine thymus.

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