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By calming down one of the hyped-up immune warriors, researchers prevented mice with massive infections from dying of septic shock.
Infusing the mice with massive numbers of these plasmids under high pressure left the animals with up to 92% less hepatitis B RNA than control animals, the researchers report in the 12 May issue of Nature Biotechnology.
A selective reduction in renal Dnase1 activity was seen in mice with massive deposition of chromatin-containing immune complexes in glomerular capillary walls.
This remarkable outcome corroborates our previous observation in bigenic mice with massive forebrain tauopathy, i.e. fibrillar tau is not neurotoxic per se [24].
Our data reveal that hBD-3 overexpressing cells, derived from the tumorigenic HEK293 cell line, form xenograft tumors in nude mice with massive infiltration of host macrophages compared with those generated from parent cells.
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All vehicle-treated mice developed progressive disease, with massive hepatic and splenic infiltration, which resulted in death in around 15 days.
In contrast to the inability of LPS/GLN to induce FHF, injection of mice with the Fas agonist antibody, Jo-2, resulted in similar levels of death in both WT and CerS2 null mice, which was associated with massive parenchymal damage accompanied by hemorrhage and tissue necrosis and cleavage of caspase 8.
Leukemic splenocytes from these commercial transgenic mice that developed fatal leukemia with massive splenomegaly were isolated at the time of the necropsy and subjected to gene expression profiling and phosphoprotein profiling in side by side comparison with CD22ΔE12-Tg CD22ΔE12-Tg
Control mice developed overt disseminated leukemia with massive splenomegaly and an average nucleated spleen cell count of 178 ± 60 × 10 (Log10 count: 7.8 ± 0.3) that was significantly higher than the nucleated spleen counts of non-leukemic control NS mice (4.6 ± 0.4 × 10, Log10 count: 6.6 ± 0.4, P < 0.0001) (Fig. 2C).
The coat of the Mpv17−/− mice turned gray early in adulthood, and 18-month or older mice developed focal segmental glomerulosclerosis (FSGS) with massive proteinuria.
Adar1 mutant mice die by embryonic day E12.5 with massive overproduction of IFN, loss of embryonic liver hematopoietic cells, liver disintegration, and widespread apoptosis (Hartner et al., 2004; Wang et al., 2004).
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