Sentence examples for mice with substantial from inspiring English sources

Thus, a condition of 'stable disease' was achieved in the group that received the combinatorial therapy In the regression trial, RIP1-Tag2 mice with substantial tumor burden and minimal life expectancy were treated beginning at week 13 [ 33].

Whereas B16 tumors grew rapidly in mice with substantial coat chimerism (termed fully chimeric mice herein), tumor growth in mice with overly white, FVB-derived skin (termed partial chimeras herein) was either marginal, yielding minute, largely necrotic tumors, or not observed at all.

All of the regimens tested were well tolerated by the mice, with no substantial effect on mouse body weight observed during treatment.

For a practical example of how the technique works for high-throughput phenotyping, the researchers used transgenic mouse embryos with substantial malformations of the developing brain and upper spinal cord.

The pronounced neutrophilia found in WT→KO mice was associated with substantial enhancement of blood neutrophil survival (Figures 7D).

Examining the offspring in the F1 and F2 generations after inter-crossing between strains showed that mice with a strong C57BL/6J background developed substantial fibrosis, which was more obvious in male mice whilst mice with the C3Hf/Kam background did not show a response [ 7].

Maturation stage ameloblasts in affected female mice were highly disorganized with substantial ECM retained in the underlying enamel (Fig.  4C).

In D2 mice, severe glaucomatous damage with substantial axon loss is detectable in over 50% of 11-month-old, 70% of 13-month-old and 80% of 19-month-old mice [ 42, 43].

Interestingly, these mice have modestly decreased lifespans, with substantial MN loss only in elderly animals.

These mice display failed limb development with substantial reduction in limb-bud size, and hypoplasia or aplasia of specific skeletal elements.

While somatic gene transfer of wtApoA-I to liver using adenoviral vectors has been shown to reduce progression [ 5, 6] and even induce regression [ 7] of atherosclerosis in mice, expression is transient and associated with substantial inflammation.