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CT images reveal an organized vascular network in tumors from Cd34+/+ mice, with large vessels of uniform diameter at the tumor periphery and an intricately branched microvascular network throughout the tumor interior (Figure 3E).

We trained sensor mice (see methods) to discriminate between the odors of mouse urine samples collected from LKR-injected mice with large tumors (Days 25 37 post cell injection) compared to genetically identical control mice without tumors.

As another example, there is generally not a significant difference in survival between vehicle- and gemcitabine-treated cohorts in KPC mice with large tumours (Olive et al., 2009).

Accordingly, we administered an anti-IL10R antibody before Pam2IDG immunization to increase the survival rate of mice with large tumors (Fig. 4D ).

Protective immune spleen cell activity in the Winn assay was inhibited by prior addition of spleen cells from mice with large tumours, causing increased tumour incidence.

Additional file 8: Systemic treatment with PODOC1 inhibits metastasis to the lung in mice with large (>500 mm 3 ) primary MDA-MB-231 tumors.

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Treatment with DOX-GA3 was also given to mice with larger tumours containing more necrosis.

Treatment with DNR-GA3 was also given to mice with larger tumours that would contain more necrosis (mean size 300-950 mm3).

Fecal HO-PCB levels and chiral signatures changed with time and differed between KO and WT mice, with larger HO-PCB enantiomeric fractions in WT compared to KO mice.

This approach permits the long-term effects of drug exposure to be assessed, both on the tumour and on the host, which is not possible in mice with larger tumours.

Our aim in this paper is to examine how habitat saturation affects maternal investment in offspring in a weakly polygynous mouse with large litter sizes, A. argenteus.

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