Sentence examples for mice with extensive from inspiring English sources

In mice with extensive hair loss from the disease, both drugs completely restored the animals' hair within 12 weeks.

Most of the mice with extensive hepatocellular carcinoma appeared behaviorally normal until the point of sacrifice.

Tumours arising in the bitransgenic mice phenotypically resembled those arising in the Myc mice with extensive involvement of the lymph nodes (Figure 5A and B).

In a previous study, we similarly observed altered lymphatic function and drainage patterns in C6 rat glioma mice with extensive LN metastasis [ 5].

The fact that we are able to detect GdPC in both subcutaneous xenografts (which have little stroma) and the authochthonous PDAC in KPC mice (with extensive stroma) suggests that its production is not specific to tumour stroma.

Six hours after bilateral renal ischemia for 22.5 min, the sickle mice showed greater renal histological injury than wild-type mice with extensive tubular necrosis extending from the corticomedullary junction through the full thickness of the cortex accompanied by marked congestion in peritubular capillaries and an acute glomerulopathy consisting of endothelialitis and mesangiolysis [ 22].

Thus, the asj mice manifest with extensive mineralization of a number of connective tissues, and the extent of mineralization is clearly modulated by the diet.

Older mice present with extensive stroke pathology, arising from a combination of the diabetic and AD phenotypes, thus leading to significant cognitive impairment.

Treatment of established tumours with three intratumoral doses of transfected fibroblasts showed a significant therapeutic effect with reduced growth or complete eradication of tumours in 90% of mice, associated with extensive leukocyte infiltration.

To clarify the role of HO-1 in fibrotic process, Kie et al showed that HO-1 knockout mice had significantly greater fibrosis 7 days after UUO compared with wild-type mice, with more extensive EMT [15].

In summary, by coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 CD109-Jak-Stat3 CD109-Jak-Stat3