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In 1948 he received a research fellowship to investigate the effects of asphyxia and jaundice in newborn mice, which led to his interest in the prevention of cerebral palsy.

An incisor tooth phenotype was originally reported in Lrp4 mutant mice which led us to investigate the tooth development in more detail in these mice.

In early studies, transformed KS cell lines such as KS Y-1 were injected into nude mice, which led to the development of KS-like lesions.

Resistin mRNA and protein expressions were markedly increased in white adipose tissue of HFD control mice, which led to elevated circulating resistin levels.

These results were corroborated in vivo by adenoviral-mediated overexpression of PlGF in normal mice, which led to increased expression of mKCC3 and mKCC4 in erythroid precursors.

It is conceivable that polarized CTCs of HD mice could have stronger surface affinity than non-polarized CTCs of LD mice, which led to the increased CTCs extravasation and metastasis observed in HD mice (Fig. 4B).

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Excess sprouting of motor nerve terminals was also found in ephrin-A5 knockout mice, which lead us to investigate a possible link between Meltrin β and ephrin-A5-Eph signaling in the development of the NMJ.

Similar investigations addressed the role of miR-155 in overexpressing transgenic mice, which leads to pre-B cell proliferation in bone marrow and spleen, followed by high grade B cell neoplasms [21].

Excess sprouting of axon terminals were also found in ephrin-A5−/− mice, which lead us to examine whether Meltrin β regulates ephrin-A5-Eph signaling in the formation of the NMJ.

The importance of MT in maintaining metal homeostasis is clearly demonstrated in studies involving exposure to heavy metals (either by diet or environment) in MT-1/2 knockout mice, which leads to metal toxicity, while MT-1/2 overexpressing mice are relatively protected from heavy metal toxicity [see review, 17].

Methanogenic Archaea also located in ob/ob mice, which lead to increasing of the efficiency of bacterial fermentation [ 29].

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