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Next, the researchers transferred intestinal contents from each of the groups into other mice, which lacked their own intestinal bacteria.
Control mice were littermate Myrffl/fl mice which lacked PDGFRα-CreERT2, so when tamoxifen is administered exon 8 is not removed and the gene remains functional (Fig. 1a).
The purpose of the present study is to further elucidate the subtype selectivity of [18F]FP-TZTP using genetically engineered mice which lacked functional M1, M2, M3, or M4 muscarinic receptors.
For this purpose, we compared host protective responses in IL-12p40 and IL-18 double-knockout (DKO) mice (which lacked both IL-12/IL-18 IL-12/IL-18 IL-12/IL-18-γ gene-disrupted (GKO) mice.
Another breed of DMP1 mutant mice, which lacked the C-terminal domain of DMP1, manifested normal BBB function.
The researchers bred mice which lacked a chemical needed for Tregs to work effectively.
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CD8 RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid organs.
For this reason, tremendous efforts have been devoted to reconstitute severe combined immunodeficient (scid) mice, which lack their own T and B lymphocytes, with human immune cells.
Here, we report that Slamf1−/− mice, which lack the hematopoietic cell surface receptor Slamf1, are completely protected from an acute lethal parasite challenge.
Neutrophil levels do not significantly change with LPS administration in TLR4−/− mice, which lack TLR4 expression on both parenchymal cells and bone marrow-derived cells.
PON1 knockout (PON1−/−) mice, which lack PON1, represent a highly sensitive mouse model for toxicity associated with exposure to CPF or CPO.
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