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The eggs were then implanted into female mice, which carried them to term.
We therefore bred triple transgenic mice which carried conditional (floxed) Slc32a1 alleles in addition to Chat i-Cre and Rosa26 lsl-ChR2-EYFP.
Female offspring of these mutator mice, which carried approximately 30 mutations randomly distributed throughout the mitochondrial genome, were continuously backcrossed to wild-type males to remove the mutant POLG gene but allow the transmission of the heteroplasmic mtDNA mutations [50].
Olig2-Cre-ER transgenic mice were crossed to Rosa26-loxP-STOP-loxP-EYFP reporter transgenic mice to yield OCE/R transgenic mice, which carried a heterozygous Cre transgene and homozygous reporter transgenes.
From these results, we calculated that the mice, which carried the PD risk-associated allele Rep1-261 bp, harbored significantly elevated levels of human SNCA-mRNA, amounting to a nearly 70% increase over those mice that carried the 'protective' genotype, allele Rep1-259 bP (P < 0.0001).
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Complete loss of Stat3 was observed in islets from mice, which carry two floxed Stat3 alleles and the Pdx1-Cre transgene.
Three years later, in 1996, the researchers reported in Nature that Ames dwarf mice, which carry a mutation in a gene called Prop1, live 50% longer than normal mice.
In addition, a gene of an acceptor can be replaced by the gene of a donor, as in the case of transgenic mice, which carry healthy or malfunctioning human genes.
In fluorescence imaging, fluorescently tagged agent is injected in mice which carry cells or tissue expressing a florescent transgene, imaged using different light tight highly sensitive CCD camera [18].
Here, we have used genetically engineered mice, which carry specific benzodiazepine-insensitive GABAA receptor subunits, to test whether diazepam, a frequently used classical benzodiazepine, exerts antihyperalgesia after systemic administration in the formalin test, a model of tonic nociception.
A long drought in the southwest has reduced predator populations, leading to an explosion of white-footed mice, which carry Hantavirus.
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