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But while research in mice is necessary, the report said, it is not sufficient to make advances in treating human diseases.

Reversible regulation of endogenous genes in mice is necessary for addressing multiple important biological questions.

Conditional deletion of these FGFs using bone cell-specific Cre mice is necessary to study their roles during bone development.

Here, we have shown that downregulation of GABAergic signaling after traumatic brain injury in mice is necessary for rewiring of the CST and spontaneous recovery of motor function.

Thus, a "cleaner" model (e.g., FCG mice) is necessary to disentangle the potential effects of gonadal and genetic sex on emotionality.

Studies over the last 2 decades clearly revealed that the requirement for immunoproteasomes for pathogen elimination or autoimmune response varies markedly between animal models and further studying of immunoproteasome-deficient mice is necessary for complete understanding of the contribution of individual proteasome subunits to the immune response to infectious or self-antigens (35).

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There are circumstances where both hemizygous and homozygous transgenic mice are necessary to explore the role of MYCN in neuroblastomas.

However, this was only observed in one animal, and larger numbers of mice are necessary to determine if this is a significant phenotype.

Further studies to evaluate time-dependent changes in hormone levels and cellular activities, as well as age-related changes of PR in the WT mice are necessary.

Because our present studies only examined viral titers on day 8 of infection, studies to evaluate viral titers on day 14, 21 and 28 of infection in MY-24-treated mice are necessary to determine when the virus is cleared from the blood and tissues, and to assess anti-TCRV neutralizing antibody levels.

Thus, further repertoire studies in normal old mice are necessary to validate this.

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