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Modeling chronic late-onset human ataxias in mice is difficult because of their short life-span.
However, arterial blood sampling in mice is difficult, and other methods have been accepted for kinetic analysis [14, 15].
Since arterial blood sampling in mice is difficult, an alternative method to obtain the arterial plasma input curve used in the kinetic model is proposed.
Recreating those painful withdrawal symptoms in mice is difficult, leading some researchers to question whether the rodents are a good model for alcohol addiction.
However, measuring respiration in newborn mice is difficult and commercial components are expensive and often require modification, creating a barrier and limiting our understanding of the short and long-term effects of birth complications on respiratory function.
Due to their shorter life spine [40], obtaining Ag Cav-1 KO mice is difficult.
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Mice: Male mice are difficult to keep together in groups without fighting.
The mice are difficult to breed because mutations often render them sterile.
However, as the Rab10 mutation in mice was difficult to study due to the severity of the phenotype, conditional knockout strategy is required for further clarification of Rab10's function.
Sperm from C57BL/6 mice are difficult to cryopreserve and recover.
For example, most dko mice are difficult to breed and are often not commercially available.
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CEO of Professional Science Editing for Scientists @ prosciediting.com