Although osteoclasts in TRAF6-deficient mice are inactive, and the splenocytes of our IFN-γR KO mice show low levels of TRAF6, the osteoclasts derived from the splenocytes of both the IFN-γR KO mice and the wild-type mice were indeed active, as proved with the pit-forming assay.
These results show that the mouse PLCζ H435P mutation is inactive in mouse eggs, whereas the H435A mutation retains Ca2+ oscillation-inducing activity.
These outcome measures were substantially reduced, however, in Cyp2e1− null mice (genetically modified mouse in which Cyp2e1 gene is inactive) compared with wild-type control mice, suggesting that CYP2E1 is essential for development of gut leakiness.
Control experiments included treatment of mice with Avastin that recognizes and neutralizes human VEGF but is inactive against mouse VEGF.
These molecules enhanced insulin secretion in islets isolated from wild-type mice but was inactive in islets from GPR40−/− mice.
The results demonstrated that the induced CNV in Flt-1 tk −/− mice was accompanied with higher VEGF levels (n = 10; p <0.005; Figure 2C,D), strongly suggesting that CNV occurs due to disruption of sFLT-1, but not of mFLT-1 activity (which is inactive in these mice).
In rats and mice, phthalates are inactive in uterotrophic assays and do not induce vaginal cornification (Kanno et al. 2003; Zacharewski et al. 1998).
Recent evidence showed in mouse skin that arsenite [As III)] is inactive as a carcinogen, but it powerfully enhances UVR carcinogenesis when added to the drinking water at concentrations < 5 mg/L (Burns et al. 2004; National Research Council 1999; Rossman et al. 2001 , 2002.
But it is inactive these days.
