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To determine whether INI mice displayed altered overall activity or altered circadian patterns of activity (perhaps reflecting the altered evening levels of Htr2c mRNA), we monitored wheel-running behaviour.
Pink1−/− mice displayed altered expression of many genes that regulate innate immune responses and the MAPK pathway (Table 1).
We first show that within the SC/CA1 pathway, Cdk5 KO mice displayed altered LTP-inducing TBS topography.
CD146 nervous system knockout mice displayed altered locomotor activity compared with their wildtype counterparts [ 15].
In behavioral studies, Sema5A mutant mice displayed altered patterns of social interaction compared to control animals, being less willing to interact with unfamiliar mice.
Skin fibroblasts isolated from DDR2-/ mice displayed altered mRNA expression of a cluster of collagens, proteoglycans, integrins and MMPs that have been previously correlated with DDR2 expression, and reduced LOX, LH1 and SPARC mRNA levels and proteins.
Similar(54)
Concomitantly, adult dcc +/− mice display altered mesocorticolimbic DA-mediated behaviors including blunted amphetamine-induced locomotion and reward, and resistance to amphetamine-induced deficits in prepulse inhibition [17] [19][20].
Genetic animal models of obesity (ob/ob and db/db mice) display altered centrally-mediated sickness behaviour in response to acute inflammatory stimuli such as lipopolysaccharide (LPS).
aSyn knockout mice display altered DA release in response to paired stimuli, reduction in striatal DA and an attenuation of DA locomotor response to amphetamine.
Bth/ Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10].
BMP8B is also expressed in the hypothalamus, and Bmp8b −/− mice display altered neuropeptide levels and reduced phosphorylation of AMP-activated protein kinase (AMPK), indicating an anorexigenic state.
Related(18)
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