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Rothman SM, Herdener N, Camandola S, Texel SJ, Mughal MR, Cong WN et al. 3xTgAD mice exhibit altered behavior and elevated Abeta after chronic mild social stress.
The present study was designed to assess whether adenosine A2a receptor knockout mice exhibit altered purine utilisation in brain nuclei.
Our findings are consistent with reports that VDR KO mice exhibit altered cytokine profiles, T cell populations and antibody responses, and are highly susceptible to colonic inflammation with age [36], [37].
Currently, our understanding of the significance of the GABAergic system in cochlear development and function is rudimentary, and thus the finding that the α9−/− mice exhibit altered GABAergic system expression may indicate that this mouse line could be useful in the future to further explore the role(s) of the GABA system in auditory periphery.
In summary, our data implicate a role for altered γ-secretase activity during aging in the development of sporadic AD and neurodegeneration; aged mice exhibit altered specificity for Aβ40 and Aβ42 production and decreased Notch1 processing, both of which are reminiscent of certain PS FAD mutations that result in the development of early onset AD.
Enzymatic activity of PARP-1 oscillates in response to feeding stimuli, and Parp1 knockout mice exhibit altered circadian rhythms and CLOCK BMAL1-dependent gene expression.
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Sporadic mice exhibiting altered motor ability in either the hanging wire or the rotarod tests were excluded from further experiments.
However, DKO mice exhibited altered pain sensitivity to an acute thermal stimulus.
Neither KO nor Het mice exhibited altered operant responding for food as a reinforcer.
We found that the Per2-mutant mice exhibited altered levels of p-CREB, but not p-ERK.
We also used immunohistochemistry to assess whether the spinal dorsal horn of Entpd3 -/- mice exhibited altered organization in comparison with that of WT animals.
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