Both androgen receptor knockout (ARKO) and brain-specific ARKO mice display changes in mating behavior (51); however, analysis of mating behavior in LCARKO mice identified no significant difference in the number of successful matings compared to controls (data not shown), demonstrating that any targeting of AR in the brain using Fabp4-Cre has minimal phenotypic impact.
Similar to the effect observed in young L2AKO, aged L2AKO animals exhibited lower WAT weight and smaller adipocyte size than age-matched Ctr mice, but differences between both groups decreased as the oldest Ctr mice group displayed changes in the same direction as the L2AKO mice (Fig. 5C, I, J).
Their mice also displayed changes in arterial pulse waveform, suggesting a vascular contribution to hypertension not previously appreciated.
Per2Brdm1 mutant mice showed alterations in parameters specific for osteoblasts whereas mice lacking Cry2−/− displayed changes in osteoclast specific parameters.
However, ovariectomized female M5R−/− mice displayed phenotypic changes similar to male M5R−/− mice, strongly suggesting that estrogen plays a key role in the observed gender differences.
Histological analysis revealed IRS869 treated mice displayed profound changes in plaque composition.
Following exposure of neonatal mice to 80% O2 or room air (RA) for either 14 or 29 days, lungs of hyperoxic mice displayed histological changes consistent with BPD.
Moreover, although Y1 receptor KO mice displayed moderate changes in acquisition and delayed extinction, Y1/Y2 receptor double KO mice exhibited strongly accelerated fear acquisition and severe extinction deficits.
Anhedonic and non-anhedonic mice displayed substantial changes in clusters of genes involved in specific biological functions important to sustain various CNS processes (Table 4).
The white matter of thoracic spinal cord of βLKB1KO mice displayed morphological changes, displaying some of the characteristics of axon degeneration: large foci of disrupted, vacuolized and demyelinated axons with disorganized microtubules.
