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Genome-wide DNA methylation assays have become increasingly common, and this has enabled characterization of DNA methylation in distinct stages across differentiating cellular lineages.
Our data show that CD44 is epigenetically regulated in lymphoma and undergoes de novo methylation in distinct lymphoma subtypes like BL.
Importantly, the proposed link between intragenic methylation and the regulation of alternate transcription (Maunakea et al. 2010) suggests that different levels of methylation in distinct tissues or developmental stages could have important phenotypic consequences.
Thus, CD44 might in fact represent a TSG undergoing de novo methylation in distinct lymphoma subtypes like BL. Methylation of TSG has biological relevance if hypermethylation of the promoter region inhibits gene expression.
A comprehensive analysis of human mammary cell lines and patient-derived tumors revealed marked differences in PREX1 promoter methylation in distinct breast cancer subtypes that inversely correlate with P-REX1 expression levels.
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5 As methylation occurs in distinct genomic areas, methylated markers in tumour tissue 6 and in body fluids 7 are likely targets for also detecting cancer in its early forms.
Histones can be methylated on different lysine residues and so can undergo different degrees of methylation, resulting in distinct effects on transcription regulation (Ohtani and Dimmeler, 2011).
Thus, it seems that DNA methylation patterns change significantly in early childhood in specific asthma- and allergy-related genes in peripheral blood cells, and early exposure to farm environment may influence methylation patterns in distinct genes.
Some previous studies reported that aberrant DNA methylation occurred in distinct diseases [ 30].
Taken together, by integrating data from multiple levels, we show that subgroup-specific differential DNA methylation occurs in distinct genomic contexts.
To characterize the underlying regulatory potential of UC DMRs and show that differential methylation occurs in distinct sequence contexts, we leverage ENCODE data on chromatin states across nine cell lines [ 17].
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