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Taken together, we conclude that RETN is not expressed in human isolated fat cells and that reports claiming positive results have methodological shortcomings which have led to spurious conclusions.
The key methodological shortcomings which introduced bias were absent/unclear randomization procedures and concealed allocation.
The current literature suffers from many methodological shortcomings which needed to be considered in future studies.
Two systematic reviews of MBSR interventions for the treatment of anxiety and depression emphasize the methodological shortcomings which create uncertainties about the efficacy of treatment.
Studies of PTSD following critical illness are characterized by significant methodological shortcomings, which raise key questions about the actual prevalence rates of PTSD and the generalizability of study findings.
Studies have shown that psycho-educational interventions may improve PDwS and primary caregivers' outcomes, but many of the published RCTs have significant methodological shortcomings which limit the comparability of studies and weaken the validity of the conclusions drawn about their effectiveness.
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The cited studies exemplify interesting design features and advances in methods of data analysis and certainly contribute to the knowledge base in educational research; however, methodological shortcomings, some of which are unavoidable even in the best of circumstances, urge a more cautious interpretation than that of strict "cause and effect".
As a result the 2012 census had the largest coverage in Chilean history: 98.34% of households.Chile has a tradition of discussing the technical merits of its statistical data and their shortcomings, which leads to continuous methodological improvement.
We extracted methodological themes and, within these, identified the areas in which methodological shortcomings with detrimental effect on quality were evident.
Several methodological shortcomings were identified, of which spectrum bias, bias due to the use of an inadequate reference standard and verification bias may seriously have affected the results.
The data Mr. Son employs to make his negative case are subject to a number of methodological shortcomings, not the least of which being a bias toward smaller, more densely populated countries.
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Justyna Jupowicz-Kozak
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