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Instead, as our paper shows, the contrarians have presented a variety of contradictory alternatives based on methodological flaws, which therefore have failed to convince scientific experts.
These findings might have occurred as a result of several important methodological flaws, which have been discussed elsewhere [ 19].
This allows methodological flaws, which can lead to bias, and sources of variation that might lead to heterogeneity, to be identified.
Existing studies on these associations have been considerably limited because of methodological flaws, which may account for controversial findings that have been reported.
Therefore, we might conclude that the pooled effect estimates reported in systematic reviews or meta-analyses of nursing interventions were susceptible to methodological flaws, which seriously weaken confidence in the estimated treatment effect.
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Methodological flaws were identified, which complicated interpretation and limited conclusions; hence, recommendations for future research are suggested.
A general methodological flaw in studies which analyze the polymorphism in consecutive series of patients treated with the same drug is that the predictive value of these polymorphisms with respect to drug sensitivity cannot be discriminated from the prognostic value.
However, only 238 patients were included from five trials, most of which contained important methodological flaws.
Early studies – many of which have had methodological flaws – suggested that LMWHs may indeed prolong survival in patients with cancer.
The association rejects the Institute of Medicine's conclusions because the studies on which they were based had methodological flaws, he said.
Poor research, which can suffer from serious methodological flaws, may then be relied upon to make critical treatment decisions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com