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As an extension of his study, this research proposes a new type of DEA-DA, or "Extended DEA-DA", that can overcome some methodological drawbacks of its original formulation, but simultaneously maintaining its discriminant capabilities.

Table  2 summarises the most important methodological drawbacks of the studies on hypoallergenic formula [ 9].

The methodological drawbacks of studies on diets in CKD are similar to those of dialysis: randomization of peritoneal dialysis versus haemodialysis is considered 'unethical and unpractical'.

The methodological drawbacks of employing a composite end point are clearly perceived in the study: while substantial risk reductions were reported for the losartan group with regard to doubling of serum creatinine and end-stage renal disease, the death rate was relatively higher.

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The present paper gives a summary of reasons for categorisation and methodological drawbacks of this approach.

Many of the studies evaluating the influence between PTH and magnesium are not controlled well enough or suffer from other methodological drawbacks to draw firm conclusions.

The development of gastric tonometry as a practical clinical technique has been limited by both methodological drawbacks and problems of interpretation.

The aim of this review is to analyze the major methodological drawbacks in mouse models of depression with a focus on its principal feature, anhedonia, in a chronic stress paradigm, and to share with the reader several procedural modifications resulting from our own experiences with a chronic stress model in C57BL/6N mice.

The EORTC has led on several published reviews of PRO in RCTs, showing that the application of PROs in many trials was plagued by important methodological drawbacks, limiting the generalizability of the results [ 12- 15].

These indirect analyses look promising and are very appealing to the reader but actually have a number of methodological drawbacks, and therefore findings need to be interpreted with caution.

Finally, we are aware of methodological drawbacks in using BiSSE models when the taxonomic coverage is not exhaustive or below 300 terminals ([ 83], see [ 84] for a discussion on model inadequacy), so further examination of these trends with other methods is necessary.

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