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Methodological weaknesses of studies evaluating the efficacy of percutaneous methods preclude definitive conclusions.
The absence of hypotheses (Elshahawi et al. 2011; Hellvin et al. 2012), post hoc analyses (Elshahawi et al. 2011) or the description of the type of post hoc analysis used (Lebowitz et al. 2001) may also be viewed as methodological weaknesses of some of the studies.
The more recent trials (Bowden et al. [2000]; Calabrese et al. [2003]; Bowden et al. [2003]; Weisler et al. [2011]) overcome many of the methodological weaknesses of the older trials of lithium that have been described in the past such as lack of intention-to-treat analysis, masking of treatment allocation, size, diagnosis, and discontinuation artifacts (Burgess et al. [2001]).
Because of the small number of institutions involved in the treatment of this disease, number of patients, and methodological weaknesses of the trials it is therefore not possible to draw definitive conclusions about the superiority of PT with respect to the photon techniques currently available for the treatment of NSCLC.
Finally, methodological weaknesses of the framework can be assessed.
And of course, updates should also try to improve methodological weaknesses of the reviews.
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Nonetheless, the lack of a standardized pain management is a methodological weakness of the study.
In part, the methodological weakness of the health workforce management research resides in insufficiently rigorous studies.
A key methodological weakness of this model is its lack of standardization of the induced lung injury, as can also be seen in our results.
However, the practical limitation of not being able to perform a randomized controlled trial automatically implicates the major methodological weakness of the proposed study.
Secondly, methodological weakness of the study design and the lack of randomisation and blinding of the assessor may limit the generalizability of our findings.
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