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However, because of the invasiveness of surgical myotomy, its higher cost and the methodological flaws of this RCT, pneumatic dilation remained the preferred choice.
Methodological flaws of pharmacologic BRS estimation mainly reside in the manual selection of the raw data segment to be evaluated which lacks objectivity.
The methodological flaws of this study (exclusion of a substantial number of patients after randomization limiting the benefits of randomization) should have been specifically highlighted in my opinion.
The first review was published in 2010, 12 which could not draw a conclusion due to the serious methodological flaws of the included studies.
Given the methodological flaws of the included studies, the available evidence is insufficient to recommend acupuncture as an evidence-based treatment option for ankle sprain.
In addition, the methodological flaws of the included trials and inconsistent findings disable us to recommend any specific CHM for recurrent miscarriage.
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There can be many reasons for these difficulties, some of which are the result of methodological flaws, for example genotyping errors.
Among those critical of the use of this theory, Whitsett and Winslow suggested that many investigations were characterized by methodological flaws, misrepresentation of results and gross misunderstanding of the theory [ 21].
The E.P.A. found that all seventeen atrazine studies, including Hayes's, suffered from methodological flaws — contamination of controls, variability in measurement end points, poor animal husbandry — and asked Syngenta to fund a comprehensive experiment that would produce more definitive results.
Identification of multiple methodological flaws and sources of heterogeneity in currently available prognostic factor studies should contribute to improve design and reporting of future prognostic and predictive factor studies.
In the debate about reasons to promote the development of practice guidelines, few have questioned whether the variations are real, or alternatively, whether they are simply a function of methodological flaws in the measurement of medical practices themselves, the result of variations in practice patterns across groups of patients with a similar diagnosis, or both.
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