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Attention biases toward food-related stimuli were examined as mediators of normal, healthy motivated behavior.
This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning.
Our study demonstrates that segmental duplications define hotspots of chromosomal rearrangement, likely acting as mediators of normal variation as well as genomic disease, and it suggests that the consideration of genomic architecture can significantly improve the ascertainment of large-scale rearrangements.
Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes.
Because olfactory cues are important mediators of normal social interactions, we tested whether olfaction was normal in Mbd5 +/GT mice.
Many genes previously confirmed as polymorphic have functions in metabolism and immunity, and likely act as mediators of normal human variation as well as genomic disease.
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MEK inhibitors (MEKi) PD0325901 and AZD6244 (Selumetinib) are drugs currently under clinical investigation for cancer treatment, however the Ras MAPK pathway is also an important mediator of normal bone cell differentiation and function.
However, NO is also a mediator of normal physiological responses in the body and is produced by chondrocytes from normal cartilage.
Severe ADAMTS13 deficiency (activity generally < 10%) results in insufficient processing of von Willebrand factor (VWF) — a critical mediator of normal platelet tethering.
The Ets1-mediated phenotype is accompanied by a variety of changes in gene expression including alterations in Notch signaling, a crucial mediator of normal skin differentiation.
Also, while EGF is an important mediator of normal mammary gland development and neoplastic transformation, the value of inhibiting EGF functioning in the treatment of breast cancer remains uncertain.
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