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Their importance has been so far underestimated although many of these compounds are crucial mediators of physiological and ecological functions in other organisms.
GPCRs are important mediators of physiological responses, as well as therapeutic targets [40].
More research is needed to measure circulating adrenal steroids, key mediators of physiological stress, and related hormones important for growth and development (i.e., growth hormone).
Nuclear receptors are key mediators of physiological responses against external and variable compounds.
VEGF and b-FGF are critical mediators of physiological as well as pathological angiogenesis.
Despite the existence of so many questions to be answered, the YAP/TAZ transcription coactivators are undoubtedly important mediators of physiological signals in regulation of organ size control, regeneration and tumorigenesis.
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VEGFA is a fundamental mediator of physiological and pathophysiological angiogenesis [32], and acts through tyrosine kinase receptors.
VEGFR2 is recognized as the principal mediator of physiological and pathological effects of VEGF on endothelial cells, which include proliferation, migration, survival, and permeability [ 67].
This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning.
These expression changes may be molecular mediators of important physiological modifications previously observed in the aging brain.
Thyroid hormones (THs) are potent mediators of several physiological processes, including embryonic development, cellular differentiation, metabolism, and cell growth.
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