Sentence examples for mediates translocation of from inspiring English sources

Diphtheria toxin consists of an A-fragment that inactivates elongation factor 2 and a B-fragment that both binds to the toxin receptor and mediates translocation of the A-fragment across cellular membranes to the cytosol.

The Sec pathway mediates translocation of protein across the inner membrane of bacteria.

The cag PAI encodes a T4SS that mediates translocation of bacterial virulence factors into the host cell [ 5].

C2IN is the enzymatic inactive domain of C2I, which interacts with C2IIa and mediates translocation of C2I- or C2IN-derived fusion proteins through C2IIa pores across endosomal membranes.

Additionally, the interaction of NS3 and NS5A with actin and tubulin in the microtubule network mediates translocation of the HCV replication complex to LDs.

The identical protein dependence of both [H]M5-DLO and [H]M7-DLO flipping is consistent with the proposal that the same flippase mediates translocation of both precursors.

Our data show that dimeric SecA may mediate translocation of the preprotein in an asymmetric manner.

Chemokines and their receptors play an important role in the immune system by mediating translocation of leukocytes towards sites of inflammation [1].

In the case of Autotransporters the b-barrel is proposed to mediate translocation of the passenger domain to the cell surface through the pore.

In the present study the activation of γδ+ T cells require live CagA positive bacteria but it was not observed after stimulation with the purified CagA protein alone, suggesting the need for metabolically active bacteria able to mediate translocation of CagA into the lymphocytes.

CPPs are able to mediate translocation of a conjugated cargo (e.g., anticancer therapeutics) across plasma membrane, providing an effective and nontoxic mechanism for drug delivery [ 8].